When NAD+ Isn’t the Answer

When NAD+ Isn’t the Answer

A longevity coach did all the right things — supplements, tracking, Oura ring metrics, morning sleep/HRV/readiness checks — and still hit brutal afternoon crashes that NAD+ couldn’t touch. The clue turned out to be impaired mitophagy: old, damaged mitochondria were piling up faster than her cells could clear them out. The pattern also lined up with five months without a menstrual cycle, hormone replacement therapy that had drifted too low until recently corrected, and a year of too much work plus too little movement.

Gobble's Take: If your dashboard looks heroic but your energy keeps face-planting, the mitochondria may be filing a complaint behind your back.
Source: Perplexity Search

The Aging Playbook Still Starts With the Basics

A systematic review on healthy aging keeps landing on the same durable levers: nutrition, physical activity, mental health, and social relationships. It points to a Mediterranean-style diet, plant-based protein for maintaining muscle mass, and regular exercise — aerobic, resistance, and balance training — as core supports for cardiovascular health, bone density, mobility, and even protection against cognitive decline.

Gobble's Take: The flashiest longevity tools may get the headlines, but the boring stuff is still doing the heavy lifting.
Source: Perplexity Search

In Case You Missed It

Yesterday's top stories:

• Longevity's money problem: too much target-hunting, not enough systems thinking
• "Factory resets" are moving from hype to human trials
• Biohacking is growing up — mostly