Longevity Lab
Science-backed longevity news
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Longevity means everything — and nothing — depending on who's talking
Longevity has become a cultural Rorschach test. For scientists, it's the study of how we age and whether that aging can be slowed or altered. For Silicon V
Aging stops being a vibe and becomes a to-do list
A new PubMed review reframes aging not as fate but as a set of targetable mechanisms. The field is increasingly going upstream—attacking core processes rat
Rewinding liver age one gene at a time
A single gene, dialed up, reversed signs of aging in mouse livers. In Nature Communications, a team at Bar-Ilan University with collaborators at the US Nat
Gene editing is moving from “interesting biology” to “one-and-done” ambition
A few people were born with a “broken” form of the PCSK9 gene, and they ended up with low LDL and striking protection from heart disease. That natural oddi
Bryan Johnson Just Ditched Your Favorite Longevity Drugs
The reads worth your time on longevity science and the relentless pursuit of a longer, healthier life often hide in plain sight, far from the daily churn o
Seven supplements walk into a lab — not all of them make it out
The longevity conversation online still swings between exaggerated hype and "anti-aging" snake oil. The reality is messier: aging is a complicated process
Why are "longevity bros" so icky?
The whole vibe here is “truthiness” welded onto Dunning Krugerification: if it feels true, it must be true; if it’s health advice, it must come from someon
Longevity whirlwind: plasma exchange, gene therapy, and Liz Parrish doing all of it first
The latest longevity circuit sounds less like a conference and more like a live-fire lab meeting. Dr. Mike's newsletter recaps a whirlwind of gatherings, a
The Weight Loss Drug Making Ozempic Look Slow
A biohacker dropped from 203 pounds to a stunning 115 pounds in just one year using a triple-hormone drug.
The Triple-Hormone Weight Drug Beating Every Number — With One Buried Catch
Nearly 1 in 5 people in retatrutide's highest-dose Phase 3 trial reported uncomfortable skin sensations — a side effect that never appeared in Phase 2, and
Your Gut Bacteria Know How Old You Really Are — And They Might Be Able to Change the Answer
Algorithms can now predict your biological age more accurately from your gut bacteria than from your birth certificate — and the microbiomes of people who
The FDA Pulled the Plug on Your Peptide Stack — And the Gray Market Exploded Anyway
Sam Altman personally wrote a $180 million check to a startup trying to reverse aging — and that was just the opening bet.
Your DNA Sets the Clock. Science Is Learning to Wind It Back.
Half of how long you live was decided before you were born — and the other half is where the fight happens.
Cornell Found Something in Your Muscles That Changes Everything About Vitamin B12
A Cornell study just found that vitamin B12 deficiency impairs skeletal muscle mitochondrial energy production — and supplementing it in aged mice actually
A Half-Trillion-Dollar Signal That the Longevity Era Has Officially Begun
A physicist who studies aging just made the most important financial argument for longevity research anyone has ever put into a Reddit post — and the numbe
A UPenn Lab Just Cut HPV in Saliva by 93% — With Chewing Gum
A UPenn lab's bioengineered chewing gum cut HPV in saliva by 93% and dropped two cancer-linked oral bacteria to near-zero. Plus: biohackers brace for the FDA peptide crackdown.
One-Third of Americans Are Accelerating Their Aging Every Night — New CDC Report
A third of all American adults — more than 100 million people — are chronically sleep-deprived, and according to the CDC, most of them don't consider it a
The Weight-Loss Drug That Protects Your Heart Even When It Doesn't Shrink Your Waist
GLP-1 drugs like Ozempic are protecting hearts in people who never lost a pound on them — and nobody has a clean explanation for why.
Two Cheap, Already-Approved Drugs Stack to Add the Equivalent of ~20 Human Years in Mice
Two FDA-approved drugs stacked together just extended mouse lifespans by 30% — and researchers are already drawing up human trial protocols.
Your Brain Tells Your Fat to Burn — Via a Hormone Called Irisin
A hormone your muscles release mid-workout is quietly rewriting the rules on what "trying harder" actually does to your fat tissue — and it has nothing to
Biohackers Are Ditching TB-500 After Cancer Warnings Hit Home
Bryan Johnson spent $2 million this year reversing his skin age by 9 years—then called sleep his #1 longevity drug, free for everyone.
After 20 Years and Hundreds of Compounds, One Drug Keeps Winning: Rapamycin
Rapamycin has extended mouse lifespan by up to 26% — and after 20 years of rigorous testing, nothing else has even come close.
Rapamycin Just Matched Calorie Restriction Across 167 Lifespan Studies
A meta-analysis of 167 studies across eight species says rapamycin extends life as consistently as dietary restriction. Plus: a sports scientist's case against the longevity industry, and fisetin matching pharmaceutical senolytics in animals.
Your Doctor's Next Prescription Might Be "Make a Friend"
Lacking strong friendships can be as deadly as smoking 15 cigarettes a day — and no supplement stack fixes that.
The Secret to Cheating Death? An 8 p.m. Bedtime.
Biohacker Bryan Johnson eats his last meal of the day at 11 a.m.
Your DNA Is Not Your Destiny (But It's More Powerful Than We Thought)
Your genes may control up to half your lifespan, but your daily choices can still add 5.5 years to your life—even if you drew the genetic short straw.