Longevity Lab
Science-backed longevity news
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Epigenetic clocks stopped being vibes. Now they keep receipts.
41 human studies have already reported effects on at least one next-generation epigenetic clock.
Bryan Johnson’s protocol is the headline, but the real story is diminishing returns
$2 million a year, versus roughly $5,000 to $20,000 for about 80% of the effect — that’s the longevity math flex today.
The silent fire of ageing
Some ageing cells stop dividing but refuse to die.
The plan to prevent cancer before it starts
50 cancers at once is the kind of number that makes "preventive medicine" sound less like wellness fluff and more like a hostile takeover of oncology.
When NAD+ Isn’t the Answer
Five months without a menstrual cycle was the canary in the mitochondria coal mine.
Longevity's money problem: too much target-hunting, not enough systems thinking
~$20B is already being poured into pharmaceutical-focused longevity initiatives.
Anti-aging graduated from fringe — now comes the hard part
2025 is the year the longevity debate stopped being polite.
The annual physical was built for a different century
61,000 people. Consistent sleep-wake timing — not just sleep length — was tied to a 20–48% lower all-cause mortality in one 2024 Oxford study.
Longevity’s trust problem is the story
Aging biology is one thing; proving a consumer product, clinic protocol, or supplement meaningfully extends human healthspan is another.
The LongevityShow made longevity look less like a niche and more like an operating system
150 speakers and more than 100 organisations showed up for the LongevityShow, where continuous glucose monitoring and biological age testing were front and
Ryan Cole, the "immortality elixir," and a very public flip
2025: a republished post says a "DNA rejuvenation elixir" cooked up at Harvard was greenlit by MAHA-FDA for first-in-human trials.
Gene therapy just entered human trials for age-related eye disease
2012 is doing a lot of heavy lifting today — it's the Nobel Prize year behind the reprogramming science now quietly colonizing the longevity conversation.
Eat These Foods + Spices for 8 Weeks To Get 3 Years Younger
3 years younger in 8 weeks is the kind of longevity headline that makes a plate look a lot more powerful than a lab.
AI, immortality, and the biotech hangover
2032 is the year one source says "longevity escape velocity" arrives — and then calls that cope.
The brain nutrient most people quietly skip
90 percent of adults come up short on choline.
Aging Is a Dashboard, Not a Single Dial
11,000 transcriptomes pooled across more than 25 tissues — clocks built for chronological age, normalized age, and expected mortality.
Immune aging is a split screen, not a single decline
982 adults. More than a million immune cells mapped. Suddenly, "aging" looks a lot less like one story.
The anti-aging menu keeps getting more precise
41 human studies, and the longevity playbook still looks annoyingly non-magical: some interventions move next-generation epigenetic clocks, while rapamycin
Eli Lilly’s retatrutide just dropped a very loud reminder that “aging” and “weight loss” keep crashing into each other
28% of body weight is the headline number today, and it came with improved blood sugar, blood pressure, sleep apnea, and joint pain.
Aging as a Broken Record: Sinclair's Information Theory of Getting Old
One of the world's leading longevity researchers has spent over 30 years chasing a single bold idea: aging is less about damaged DNA and more about lost ep
Longevity means everything — and nothing — depending on who's talking
Longevity has become a cultural Rorschach test. For scientists, it's the study of how we age and whether that aging can be slowed or altered. For Silicon V
Aging stops being a vibe and becomes a to-do list
A new PubMed review reframes aging not as fate but as a set of targetable mechanisms. The field is increasingly going upstream—attacking core processes rat
Rewinding liver age one gene at a time
A single gene, dialed up, reversed signs of aging in mouse livers. In Nature Communications, a team at Bar-Ilan University with collaborators at the US Nat
Gene editing is moving from “interesting biology” to “one-and-done” ambition
A few people were born with a “broken” form of the PCSK9 gene, and they ended up with low LDL and striking protection from heart disease. That natural oddi
Bryan Johnson Just Ditched Your Favorite Longevity Drugs
The reads worth your time on longevity science and the relentless pursuit of a longer, healthier life often hide in plain sight, far from the daily churn o
Seven supplements walk into a lab — not all of them make it out
The longevity conversation online still swings between exaggerated hype and "anti-aging" snake oil. The reality is messier: aging is a complicated process
Why are "longevity bros" so icky?
The whole vibe here is “truthiness” welded onto Dunning Krugerification: if it feels true, it must be true; if it’s health advice, it must come from someon
Longevity whirlwind: plasma exchange, gene therapy, and Liz Parrish doing all of it first
The latest longevity circuit sounds less like a conference and more like a live-fire lab meeting. Dr. Mike's newsletter recaps a whirlwind of gatherings, a
The Weight Loss Drug Making Ozempic Look Slow
A biohacker dropped from 203 pounds to a stunning 115 pounds in just one year using a triple-hormone drug.
The Triple-Hormone Weight Drug Beating Every Number — With One Buried Catch
Nearly 1 in 5 people in retatrutide's highest-dose Phase 3 trial reported uncomfortable skin sensations — a side effect that never appeared in Phase 2, and